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Home β€Ί Medicine β€Ί Zytorvi 240mg Injection
Substitutes

Zytorvi 240mg Injection

Prescription Required
Salt Composition TORIPALIMAB
Marketer DR REDDY'S LABORATORIES LTD
Prepaid Only. Non-Returnable.
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This medicine is prepaid
only and cannot be
returned once delivered.
18% OFF
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Introduction to Zytorvi 240mg Injection

Zytorvi 240mg Injection contains the active ingredient Toripalimab, a monoclonal antibody used to treat metastatic or recurrent locally advanced nasopharyngeal carcinoma (NPC).

It is used as first-line therapy in combination with cisplatin and gemcitabine for adult patients.

It can also be used as a single agent for patients with recurrent, unresectable, or metastatic NPC that has progressed following platinum-based chemotherapy.

Mechanism of Action:
Zytorvi works by blocking the PD-1 receptor, preventing its interaction with PD-L1 and PD-L2 ligands. This releases the inhibition on T cells, enhancing their activity, promoting immune surveillance, and triggering an anti-tumor immune response. Preclinical studies have shown that PD-1 blockade can reduce tumor growth.

Common Side Effects:

Nausea and vomiting

Burning or tingling sensations in the feet and toes

Decreased appetite

Diarrhea and constipation

Warnings and Precautions:

Severe immune-mediated adverse reactions can affect any organ or tissue and may be life-threatening. These reactions can occur at any time during treatment or even after discontinuation, requiring close monitoring and immediate medical attention.

Infusion-related reactions, including hypersensitivity and anaphylaxis, may occur during administration.

Patients who have undergone or are undergoing allogeneic hematopoietic stem cell transplantation (HSCT) may experience serious complications such as graft-versus-host disease (GVHD) and other transplant-related issues.

Zytorvi is contraindicated during pregnancy due to the risk of fetal harm, including potential fetal death.

Uses of Zytorvi 240mg Injection

The uses of Zytorvi 240mg Injection are:

First-line treatment for adults with metastatic or recurrent locally advanced nasopharyngeal carcinoma (NPC) in combination with cisplatin and gemcitabine
Single-agent treatment for adults with recurrent, unresectable, or metastatic NPC that has progressed after platinum-containing chemotherapy

Therapeutic Effects of Zytorvi 240mg Injection

Zytorvi 240mg Injection blocks the PD-1 receptor, preventing its interaction with the PD-L1 and PD-L2 ligands. This action stimulates T cells, enhancing their activity and restoring immune surveillance to promote an anti-tumour immune response. In preclinical models, blocking PD-1 activity reduced tumour growth.

Interaction of Zytorvi 240mg Injection with other drugs

It is important to inform your healthcare professional about all the medications you are taking, including prescription drugs, over-the-counter medications, nutritional supplements, and herbal products. Some medications may interact with Zytorvi 240mg Injection, potentially affecting their effectiveness or causing side effects.

More Information about Zytorvi 240mg Injection

Keep out of reach of children and pets. Store in the original packaging to protect from moisture. Avoid direct sunlight Store Zytorvi 240mg Injection in a refrigerator at a temperature of 2Β°C to 8Β°C. Do not freeze or shake it.

How to consume Zytorvi 240mg Injection

Your healthcare provider administers Zytorvi 240mg Injection through an intravenous (IV) line into your vein over 30 to 60 minutes. It is usually given every two or three weeks as an IV infusion. Your healthcare provider will decide the number of treatments you need and monitor your blood for potential side effects. If you miss an appointment, contact your healthcare provider immediately to reschedule.

Side Effects of Zytorvi 240mg Injection

Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.
Common side effects of Zytorvi 240mg Injection are:
Decreased appetite
Nausea and vomiting
Constipation and diarrhoea
Muscle and bone pain
Dizziness
Burning or feeling of pins and needles in feet and toes
Upper respiratory infection
Sleep problems
Rash
Fever and cough
Low levels of thyroid hormone
Serious side effects of Zytorvi 240mg Injection are:
Severe allergic reactions such as difficulty breathing, swelling of face or throat
Liver problems (e.g., yellowing of skin or eyes, dark urine)
Lung problems (e.g., shortness of breath, cough, chest pain)
Immune system problems leading to inflammation in organs
Endocrine problems
Severe infections

Safety Advice for Zytorvi 240mg Injection

Breast Feeding-unsafe
Breast Feeding
Unsafe
The Zytorvi 240mg Injection is not safe to use in breastfeeding women as it passes through breast milk.
Alcohol-Consult your doctor
Alcohol
Consult Your Doctor
It is unknown whether alcohol consumption is safe while you are undergoing Zytorvi 240mg Injection course. It is recommended to consult your doctor for better guidance.
Liver-Consult your doctor
Liver
Consult Your Doctor
You need to inform your doctor if you have any liver disorders before starting treatment with Zytorvi 240mg Injection.
Lungs-Consult your doctor
Lungs
Consult Your Doctor
Before starting treatment with Zytorvi 240mg Injection talk to your doctor if you have any lung conditions.
Driving-Consult your doctor
Driving
Consult Your Doctor
Zytorvi 240mg Injection may have a minor influence on the ability to drive or handle machines as some patients reported dizziness and fatigue. It is recommended to consult your doctor for better guidance.
Pregnancy-unsafe
Pregnancy
Unsafe
The Zytorvi 240mg Injection is not safe to use in pregnant women as it may cause fetal harm.

Word of Advice for Zytorvi 240mg Injection

Zytorvi 240mg Injection can cause severe and potentially fatal immune-mediated reactions, which may affect any organ and occur at any time during treatment or after discontinuation, requiring close monitoring. It may also cause infusion-related reactions, including severe hypersensitivity or anaphylaxis. Patients undergoing or planning HSCT should be aware of potential complications like graft-versus-host disease. Additionally, Zytorvi 240mg Injection can harm a developing fetus, so it should be avoided during pregnancy. Always follow your healthcare provider’s instructions and attend regular check-ups to manage any risks.

FAQs about Zytorvi 240mg Injection

Q1. Q1. Is Zytorvi 240mg Injection FDA-approved?

Yes, the U.S. FDA approved Toripalimab, the active ingredient of Zytorvi 240mg Injection on October 27, 2023, for use in treating specific cancers.

Q2. Q2. Is Zytorvi 240mg Injection effective?

Yes, Zytorvi 240mg Injection has been shown to be effective in treating certain cancers, particularly when combined with chemotherapy. Clinical trials demonstrate its ability to improve patient outcomes.

Q3. Q3. Is Zytorvi 240mg Injection safe?

Zytorvi 240mg Injection is generally safe when used as prescribed, but it may cause immune-related side effects. Healthcare providers monitor patients closely to manage potential risks.

Q4. Q4. What is the best time to take Zytorvi 240mg Injection?

Zytorvi 240mg Injection is administered by a healthcare provider through an intravenous infusion. The timing of each dose is determined by your treatment plan and healthcare provider's instructions.

Q5. Q5. Who should not take Zytorvi 240mg Injection?

Zytorvi 240mg Injection should not be taken by individuals with a known hypersensitivity to the drug or any of its components. It is also not recommended for pregnant or breastfeeding women due to potential risks to the fetus or infant.

Fact Box of Zytorvi 240mg Injection

Molecule Name TORIPALIMAB
Marketer DR REDDY'S LABORATORIES LTD

References for Zytorvi 240mg Injection

1. Wei XL, Ren C, Wang FH, Zhang Y, Zhao HY, Zou BY, Wang ZQ, Qiu MZ, Zhang DS, Luo HY, Wang F, Yao S, Xu RH. A phase I study of toripalimab, an anti-PD-1 antibody, in patients with refractory malignant solid tumors.
3. Zhang L, Hao B, Geng Z, Geng Q. Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China.
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Zytorvi 240mg Injection
β‚Ή95,600.00 MRP β‚Ή117,187.50
Inclusive of all taxes 18% OFF
(You Save β‚Ή21,587.50)
6 ML Injection in Vial

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