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Home β€Ί Medicine β€Ί Sigrima 420mg Injection
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Sigrima 420mg Injection

Prescription Required Cold Chain i
Salt Composition PERTUZUMAB
Marketer ZYDUS CADILA
Prepaid Only. Non-Returnable.
?
This medicine is prepaid
only and cannot be
returned once delivered.
20% OFF
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Introduction to Sigrima 420mg Injection

Sigrima 420 mg Injection is a targeted cancer therapy containing pertuzumab and trastuzumab. It is used to treat HER2-positive breast cancer, including cases that have spread to other parts of the body (metastatic) or have recurred after previous treatment. It may also be administered before or after surgery in patients whose cancer has not metastasized. Cancer develops when cells grow abnormally and uncontrollably.

Before receiving Sigrima 420 mg Injection, inform your doctor if you have any heart conditions, have undergone radiotherapy, or have a history of allergies. This medication is not recommended for children or adolescents under 18 years of age.

For patients with early-stage HER2-positive breast cancer, combining pertuzumab and trastuzumab with standard chemotherapy can help lower the risk of cancer recurrence and improve disease-free survival

Uses of Sigrima 420mg Injection

Breast cancer
Non-small cell lung cancer

Therapeutic Effects of Sigrima 420mg Injection

Human epidermal growth factor receptor 2 protein is largely present in some cancer cells and stimulates the growth of cancer cells. Sigrima 420mg Injection binds selectively to the HER2 receptors on breast cancer cells' surface, blocks them from receiving growth signals, and stops the cancer cells' growth.

Interaction of Sigrima 420mg Injection with other drugs

Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Sigrima 420mg Injection and reduce effectiveness by causing undesirable side effects.

More Information about Sigrima 420mg Injection

Store in a refrigerator between 2Β°C and 8Β°C (36Β°F and 46Β°F). It should not be frozen. Keep it in its original packaging until it is ready to be used. Keep out of the reach of children and pets.

How to consume Sigrima 420mg Injection

Sigrima 420mg Injection is a medication administered intravenously (IV) by a healthcare professional. It is important to follow the healthcare provider's instructions regarding the dosage and administration of medication. Do not double the dose to make up for missed doses.

Side Effects of Sigrima 420mg Injection

Like all medications, Sigrima 420mg Injections cause some side effects, although not everyone will experience them.
Serious:
Pulmonary toxicity (interstitial lung disease or pneumonitis)
Infusion-related reactions
Hypersensitivity reactions
Liver toxicity
Immune system effects
Severe allergic reactions
Gastrointestinal perforation (rare)
Reduced blood platelets or white blood cell counts
Common:
Nausea and vomiting
Diarrhea
Fatigue
Hair loss
Rash or itching
Muscle pain or weakness
Headache
Difficulty sleeping
Loss of appetite

Safety Advice for Sigrima 420mg Injection

Breast Feeding
Consult Your Doctor
It is unknown whether Sigrima 420mg Injection is excreted in human milk. So breastfeeding women should consult their doctor before taking it.
Alcohol-unsafe
Alcohol
Unsafe
Alcohol use can negatively affect the immune system, and patients receiving Sigrima 420mg Injection may already have compromised immune systems due to their medical condition or treatment. Therefore, it is generally recommended that patients limit their alcohol consumption or avoid alcohol entirely while receiving it.
Liver-Consult your doctor
Liver
Consult Your Doctor
Patients with pre-existing liver disease or impaired liver function may be at increased risk for the potential side effects of Sigrima 420mg Injection, including liver toxicity. So patients should discuss it with their healthcare provider before taking it.
Lungs-Consult your doctor
Lungs
Consult Your Doctor
Sigrima 420mg Injection can cause side effects, and the safety of their use in the lungs depends on several factors. Patients should consult their doctor if they have any pre-existing health condition before taking this medication
Driving-Consult your doctor
Driving
Consult Your Doctor
Patients should always monitor their response to the Sigrima 420mg Injection medication and be cautious when driving or operating machinery if they experience any side effects that may impair their ability to do so safely.
Pregnancy-Consult your doctor
Pregnancy
Consult Your Doctor
Sigrima 420mg Injection may harm the developing fetus, so it is unsafe to use it during pregnancy

Word of Advice for Sigrima 420mg Injection

If you are prescribed Sigrima 420mg Injection, or any other medication, it is important to carefully read and understand the warnings and precautions associated with the medication. Patients should be monitored for signs of an allergic reaction, such as rash, itching, or swelling, and should seek immediate medical attention if these symptoms occur. It should be used with caution in patients with severe renal impairment. Talk to the physician if you have heart problems, have had radiotherapy, or have allergic conditions. Use effective birth control during the treatment and at least seven months after the last dose. Always maintain a healthy and balanced diet to support your overall health and well-being.

FAQs about Sigrima 420mg Injection

Q1. Q1. Can Sigrima 420mg Injection cause infertility?

Sigrima 420mg Injection can affect fertility in some patients, although the extent of this effect is not well-understood. Women who wish to preserve their fertility should discuss their options with their healthcare provider before starting treatment with these drugs.

Q2. Q2. Can Sigrima 420mg Injection be used together with chemotherapy?

Yes, Sigrima 420mg Injection are often combined with chemotherapy to treat HER2-positive breast cancer. This combination therapy effectively reduces the risk of recurrence and improves overall survival in patients with HER2-positive breast cancer.

Q3. Q3. Can I take Sigrima 420mg Injection if I have TB?

If you have active tuberculosis (TB) infection, Sigrima 420mg Injection should not be used until the TB infection has been treated and is under control. These drugs can suppress the immune system, worsening TB or other infections.

Fact Box of Sigrima 420mg Injection

Molecule Name PERTUZUMAB
Marketer ZYDUS CADILA

References for Sigrima 420mg Injection

1.Roche products limited, Electronic medicines compendium (EMC), [Revised on Jan 2022] [ Accessed on 03/05/2023],
2.zhu Chenjing et al.; Safety and efficacy evaluation of pertuzumab in patients with solid tumors; Medicine; [Published on May 2017]; [Accessed on 03/05/2023
3.Sandra M Swain et al; Sigrima 420mg Injection, and docetaxel in HER2-positive metastatic breast cancer; The New England Journal of Medicine; [Published on Feb 2015]; [Accessed on 03/05/203
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Sigrima 420mg Injection
β‚Ή59,964.00 MRP β‚Ή74,995.31
Inclusive of all taxes 20% OFF
(You Save β‚Ή15,031.31)
14 ML Injection in Vial

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