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Home β€Ί Medicine β€Ί Phesgo 1200mg/600mg Injection
Substitutes
Phesgo 600mg/600mg Injection
ROCHE PRODUCTS INDIA
β‚Ή213,735.00
48% cheaper

Phesgo 1200mg/600mg Injection

Prescription Required
Salt Composition PERTUZUMAB,TRASTUZUMAB
Marketer ROCHE PRODUCTS INDIA
Prepaid Only. Non-Returnable.
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This medicine is prepaid
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16% OFF
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Introduction to Phesgo 1200mg/600mg Injection

Phesgo 1200mg/600mg Injection is a targeted cancer treatment that contains the active ingredients pertuzumab and trastuzumab. It is used to treat HER2-positive breast cancer, including cases where the cancer has spread to other parts of the body (metastatic breast cancer) or has returned after previous treatment.

This medication may also be administered before or after surgery in patients whose cancer has not spread, as part of early-stage treatment. Cancer develops when cells grow and multiply uncontrollably and abnormally.

Before starting treatment with Phesgo, inform your doctor if you have any heart conditions, have previously received radiotherapy, or have a history of allergic reactions. This medicine is not recommended for children or adolescents under 18 years of age.

For patients with early-stage HER2-positive breast cancer, combining pertuzumab or trastuzumab with standard chemotherapy has been shown to lower the risk of cancer recurrence and improve disease-free survival outcome

Uses of Phesgo 1200mg/600mg Injection

Phesgo 1200mg 600mg Injection is used to manage the following conditions:

Early breast cancer
Metastatic breast cancer

Therapeutic Effects of Phesgo 1200mg/600mg Injection

Phesgo (pertuzumab and trastuzumab) 1200mg/600mg injection is a fixed-dose combination therapy used for HER2-positive breast cancer, offering the therapeutic benefits of both monoclonal antibodies in a convenient subcutaneous formulation. Pertuzumab prevents HER2 receptor dimerization, while trastuzumab blocks HER2 signalling and triggers immune-mediated tumour cell destruction, collectively inhibiting cancer cell growth and proliferation. By targeting HER2-positive cells, Phesgo reduces tumour progression, improves survival rates, and enhances treatment convenience compared to intravenous administration.

Interaction of Phesgo 1200mg/600mg Injection with other drugs

Phesgo 1200mg 600mg has a long washout period, which can increase the risk of cardiac dysfunction when followed by anthracycline-based therapy. Patients who receive anthracyclines after stopping Phesgo may be at a higher risk of cardiotoxicity, necessitating careful monitoring of cardiac function. If possible, anthracycline-based treatments should be avoided for up to seven months after discontinuing Phesgo. Healthcare providers should assess cardiac function regularly when co-administering or sequencing these agents to minimize the risk of adverse cardiovascular effects.

More Information about Phesgo 1200mg/600mg Injection

Store the Phesgo Injection in a refrigerator between 2Β°C and 8Β°C (36Β°F and 46Β°F). It should not be frozen. Keep it in its original packaging until it is ready to be used. Keep out of the reach of children and pets.

How to consume Phesgo 1200mg/600mg Injection

Phesgo 1200mg/600mg Injection is administered subcutaneously, not intravenously. The initial loading dose of 1,200 mg pertuzumab and 600 mg trastuzumab is given over approximately 8 minutes, followed every three weeks by a maintenance dose of 600 mg pertuzumab and 600 mg trastuzumab administered over approximately 5 minutes. Injections should alternate between the left and right thighs, ensuring each new injection is at least 2.5 cm away from the previous site and avoiding areas that are red, bruised, tender, or hard. Do not split the dose between multiple syringes or injection sites. After administering the loading dose, observe the patient for 30 minutes; for maintenance doses, a 15-minute observation period is recommended to monitor for injection-related reactions. If a serious hypersensitivity reaction occurs, discontinue the injection immediately and permanently.

Side Effects of Phesgo 1200mg/600mg Injection

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. The Phesgo Injection side effects are:
Common side effects of Phesgo 1200mg/600mg Injection are:
Alopecia (hair loss)
Nausea
Diarrhea
Anemia
Asthenia (weakness)
Fatigue
Stomatitis (inflammation of the mouth)
Myalgia (muscle pain)
Arthralgia (joint pain)
Constipation
Neutropenia (low white blood cell count)
Vomiting
Radiation skin injury
Dysgeusia (altered taste)
Headache
Decreased appetite
Insomnia
Peripheral sensory neuropathy
Rash
Dry skin
Mucosal inflammation
Injection site reactions (e.g., pain, redness)
Cough
Serious Side Effects:
Febrile neutropenia (fever with low white blood cell count)
Neutropenic sepsis (a severe infection due to low white blood cell count)
Decreased ejection fraction (a measure of heart function)
Cardiac failure
Pneumonitis/pulmonary fibrosis (lung inflammation or scarring)
Hypersensitivity reactions, including anaphylaxis
Severe injection-related reactions

Safety Advice for Phesgo 1200mg/600mg Injection

Breast Feeding
Consult Your Doctor
It is unknown whether the Phesgo 600 Injection is excreted in human milk. So breastfeeding women should consult their doctor before taking it.
Alcohol-unsafe
Alcohol
Unsafe
Alcohol use can negatively affect the immune system, and patients receiving Phesgo 1200mg/600mg Injection may already have compromised immune systems due to their medical condition or treatment. Therefore, it is generally recommended that patients limit their alcohol consumption or avoid alcohol entirely while receiving it.
Liver-unsafe
Liver
Unsafe
Patients with pre-existing liver disease or impaired liver function may be at increased risk for the potential side effects of Injection Phesgo, including liver toxicity. So patients should discuss it with their healthcare provider before taking it.
Lungs-unsafe
Lungs
Unsafe
Phesgo 1200mg/600mg Injection can cause side effects, and the safety of their use in the lungs depends on several factors. Patients should consult their doctor if they have any pre-existing health condition before taking this medication.
Driving-unsafe
Driving
Unsafe
Patients should always monitor their response to the Phesgo 1200mg/600mg Injection medication and be cautious when driving or operating machinery if they experience any side effects that may impair their ability to do so safely.
Pregnancy-unsafe
Pregnancy
Unsafe
Phesgo 1200mg/600mg Injection may harm the developing fetus, so it is unsafe to use during pregnancy.

Word of Advice for Phesgo 1200mg/600mg Injection

If you have prescribed Phesgo 1200mg 600mg Injection, or any other medication, it is important to carefully read and understand the warnings and precautions associated with the medication. Patients should be monitored for signs of an allergic reaction, such as rash, itching, or swelling, and should seek immediate medical attention if these symptoms occur. It should be used with caution in patients with severe renal impairment. Talk to the physician if you have heart problems, have had radiotherapy, or have allergic conditions. Use effective birth control during the treatment and at least seven months after the last dose. Always maintain a healthy and balanced diet to support your overall health and well-being.

FAQs about Phesgo 1200mg/600mg Injection

Q1. Q1. Can Phesgo 1200mg/600mg Injection cause infertility?

Phesgo 1200mg/600mg Injection can affect fertility in some patients, although the extent of this effect is not well-understood. Women who wish to preserve their fertility should discuss their options with their healthcare provider before starting treatment with these drugs.

Q2. Q2. Can Phesgo 1200mg/600mg Injection be used together with chemotherapy?

Yes, Phesgo 1200mg/600mg Injection are often combined with chemotherapy to treat HER2-positive breast cancer. This combination therapy effectively reduces the risk of recurrence and improves overall survival in patients with HER2-positive breast cancer.

Q3. Q3. Can I take Phesgo 1200mg/600mg Injection if I have TB?

If you have active tuberculosis (TB) infection, Phesgo 1200mg/600mg Injection should not be used until the TB infection has been treated and is under control. These drugs can suppress the immune system, worsening TB or other infections.

Q4. Q4. Can Phesgo 1200mg/600mg Injection cause skin reactions?

Yes, Phesgo 1200mg/600mg Injection can cause skin reactions, including rash, dry skin, and itching. In some cases, these skin reactions can be severe and require treatment. Patients should promptly report any new or worsening skin symptoms to their healthcare provider.

Q5. Q5. Can Phesgo 1200mg/600mg Injection affect blood counts?

Yes, Phesgo 1200mg/600mg Injection can affect blood counts and may increase the risk of anemia, thrombocytopenia, and neutropenia. These blood disorders can cause symptoms such as fatigue, weakness, and an increased risk of infections or bleeding. Patients receiving this medication should check their blood counts regularly.

Q6. Q6. Can Phesgo 1200mg/600mg Injection be used in older adults?

Yes, Phesgo 1200mg/600mg Injection can be used in older adults. However, older adults may be at increased risk of side effects like heart-related complications or infections. Healthcare providers may need to adjust the dose or monitor more closely for potential side effects in older patients.

Q7. Q7. Can Phesgo 1200mg/600mg Injection be used in men with breast cancer?

Yes, Phesgo 1200mg/600mg Injection can be used in men with HER2-positive breast cancer. Breast cancer is rare in men, accounting for less than 1% of all breast cancer cases. However, HER2-positive breast cancer is more common in men than in women with breast cancer.

Q8. Q8. Does phesgo cause hair loss?

Yes, Phesgo (pertuzumab and trastuzumab) can cause hair loss (alopecia) as a common side effect. However, the severity of hair loss varies among patients, and not everyone experiences it. If hair loss occurs, it is usually temporary, and hair may regrow after treatment completion. If you're concerned about this side effect, discuss potential management strategies with your healthcare provider.

Fact Box of Phesgo 1200mg/600mg Injection

Molecule Name PERTUZUMAB,TRASTUZUMAB
Marketer ROCHE PRODUCTS INDIA

References for Phesgo 1200mg/600mg Injection

1.Roche products limited, Electronic medicines compendium (EMC), [Revised on Jan 2022] [ Accessed on 03/05/2023],
2.zhu Chenjing et al.; Safety and efficacy evaluation of pertuzumab in patients with solid tumors; Medicine; [Published on May 2017]; [Accessed on 03/05/2023]
3.Sandra M Swain et al; Pertuzumab, Trastuzumab, and docetaxel in HER2-positive metastatic breast cancer; The New England Journal of Medicine; [Published on Feb 2015]; [Accessed on 03/05/203];
4.chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.gene.com/download/pdf/phesgo_prescribing.pdf
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Phesgo 1200mg/600mg Injection
β‚Ή413,399.00 MRP β‚Ή493,266.56
Inclusive of all taxes 16% OFF
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15 ML Injection in Vial

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