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Home β€Ί Medicine β€Ί Pazonue 400mg Tablet
Substitutes
Pazonue 200mg Tablet
LUCIEN LIFE SCIENCES
β‚Ή3,253.00
29% cheaper
Votrient 200mg Tablet
NOVARTIS INDIA LTD
β‚Ή8,399.00
84% costlier
Votrient 400mg Tablet
NOVARTIS INDIA LTD
β‚Ή16,099.00
253% costlier

Pazonue 400mg Tablet

Prescription Required
Salt Composition PAZOPANIB
Marketer LUCIEN LIFE SCIENCES
Prepaid Only. Non-Returnable.
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Introduction to Pazonue 400mg Tablet

Pazonue 400 mg Tablet contains the active ingredient pazopanib, a type of antineoplastic medication classified as a tyrosine kinase inhibitor. It is used in adults for the treatment of advanced kidney cancer that has spread to other parts of the body. Pazonue is also indicated for certain forms of soft-tissue sarcoma, which is cancer affecting the body's supportive tissues. This medication works by blocking the activity of proteins that promote the growth and spread of cancer cells.

You should not take Pazonue 400 mg Tablet if you are allergic to pazopanib or any other component of the medicine. Before starting treatment, inform your doctor if you have any history of kidney, heart, lung, or liver issues, bleeding disorders, gastrointestinal problems, or thyroid conditions. Pazonue can elevate blood pressure, so it’s important to monitor your blood pressure regularly during treatment. No dose adjustments are needed for patients with kidney conditions.

Your doctor will likely recommend stopping Pazonue 400 mg Tablet at least 7 days before any scheduled surgeries or dental procedures, as it can affect wound healing. This medication is not suitable for individuals under the age of 18. Additionally, Pazonue may cause infertility, so it’s crucial to consult your doctor about this before beginning treatment.

Common side effects of Pazonue include diarrhea, high blood pressure (hypertension), changes in hair color, nausea, and vomiting. The cost of Pazonue 400 mg Tablet may vary depending on the retailer

Uses of Pazonue 400mg Tablet

Pazonue 400mg uses are:

Advanced renal cell carcinoma

Advanced soft tissue sarcoma

Therapeutic Effects of Pazonue 400mg Tablet

This medication acts on specific receptors to provide therapeutic relief.

Interaction of Pazonue 400mg Tablet with other drugs

Strong CYP3A4 Inhibitors such as Ketoconazole or Clarithromycin (Severe) These medicines can increase pazopanib levels in the blood, raising the risk of liver toxicity and heart rhythm problems. Close monitoring or alternative therapy is advised. Strong CYP3A4 Inducers like Rifampicin or Phenytoin (Severe) Such drugs can reduce pazopanib concentration, making the treatment less effective. Combined use is generally avoided. Proton Pump Inhibitors and H2 Blockers (Severe) Medicines like omeprazole or ranitidine reduce pazopanib absorption by lowering stomach acidity. Dose timing adjustment or alternative acid control is recommended. QT Prolonging Medicines such as Amiodarone (Moderate) Using these together may increase the risk of abnormal heart rhythms. ECG monitoring is advised during combined therapy. Statins like Simvastatin (Moderate) Pazopanib can increase liver enzyme levels when used with statins, raising the risk of liver injury. Regular liver function testing is required. Anticoagulants like Warfarin (Moderate) Pazopanib may increase bleeding risk. Closer monitoring of clotting parameters is necessary. Antacids containing Aluminum or Magnesium (Mild) These may interfere with pazopanib absorption. Taking them several hours apart helps maintain Pazonue effectiveness.

More Information about Pazonue 400mg Tablet

Avoid drinking grapefruit juice during treatment, as it can increase the risk of side effects. Male patients with female partners of reproductive potential should use effective contraception during treatment and for at least 2 weeks after the last dose. Take the tablet at the same time each day to maintain consistent drug levels. Your doctor will perform regular laboratory tests to monitor how well the medicine is working. Follow all medical advice carefully and report any unusual symptoms to your doctor promptly.

How to consume Pazonue 400mg Tablet

Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Do not take this medicine with food, as it affects the absorption of this medicine. Take Pazonue 400mg Tablet at least two hours after a meal or one hour before a meal.

Side Effects of Pazonue 400mg Tablet

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
Hypertension
Hair Colour change
Increased glucose levels
Decreased weight, decrease in appetite
Diarrhea
Nausea, vomiting
Muscle and joint pain
Headache
Shortness of breath
Tiredness
Serious
Heart problems
Bleeding from the anus, mouth
Hypothyroidism
Interstitial lung disease
Infections
Expert tips
Avoid drinking grapefruit juice during treatment, as it can increase the risk of side effects.
Male patients with female partners of reproductive potential should use effective contraception during treatment and for at least 2 weeks after the last dose.
Take the tablet at the same time each day to maintain consistent drug levels.
Your doctor will perform regular laboratory tests to monitor how well the medicine is working.
Follow all medical advice carefully and report any unusual symptoms to your doctor promptly.

Safety Advice for Pazonue 400mg Tablet

Breast Feeding
Unsafe
Breastfeeding is not recommended in patients taking Biopanib 400mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby.
Alcohol-Consult Your Doctor
Alcohol
Consult Your Doctor
It is unknown whether it is safe to consume alcohol when taking Pazonue 400mg Tablet. Consult your doctor for more advice.
Liver-Unsafe
Liver
Unsafe
Pazonue 400mg Tablet is unsafe when administered in patients with severe liver diseases. Dose adjustments are necessary for moderate liver failure. Inform your physician if you have liver problems before initiating the therapy.
Lungs-Consult Your Doctor
Lungs
Consult Your Doctor
It is unknown whether Pazonue 400mg Tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving-Unsafe
Driving
Unsafe
Driving or operating heavy machinery is unsafe after taking Pazonue 400mg Tablet because you may feel dizzy, drowsy, or have blurred vision.
Pregnancy-Unsafe
Pregnancy
Unsafe
Pazonue 400mg Tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for at least 2 weeks after your last dose is necessary.

Word of Advice for Pazonue 400mg Tablet

Stay hydrated and report any unusual symptoms to your doctor immediately.

FAQs about Pazonue 400mg Tablet

Q1. Q1. What if I forgot to take Pazonue 400mg Tablet?

If you forgot to take a dose, take it as soon as you remember. However, skip the missed dose if it is nearly time for the next dose. Do not take a double dose to make up the forgotten dose.

Q2. Q2. Can Pazonue 400mg Tablet induce liver toxicity?

Yes, long-term use of Pazonue 400mg Tablet may induce liver toxicity or severe liver failure. Inform your physician if you have any liver disorders before starting treatment with this medicine. Your doctor may advise you to take certain blood tests to check your liver function periodically.

Q3. Q3. Does Pazonue 400mg Tablet change hair colour?

Hair Colour change is a common side effect of Pazonue 400mg Tablet therapy which usually develops gradually during a few months of therapy. Consult your doctor for more advice.

Q4. Q4. Is anaemia a side effect of Pazonue 400mg Tablet?

Pazonue 400mg Tablet can reduce the number of red blood cells, which transport oxygen throughout the body. A low number of red blood cells is called anaemia. This may make you feel tired and short of breath. Tell your doctor or nurse if you have these symptoms.

Q5. Q5. What are the benefits of Pazonue 400mg Tablet?

Pazonue 400mg Tablet is used to treat certain types of cancer (kidney, soft tissue sarcoma). It decreases the blood supply to the cancer tumour to slow tumour growth.

Fact Box of Pazonue 400mg Tablet

Molecule Name PAZOPANIB
Marketer LUCIEN LIFE SCIENCES

References for Pazonue 400mg Tablet

1.Highlights Of Prescribing Information - Pazopanib. [Revised on 2021] [cited 2023 Mar 24]. Available from:
2.Summary Of Product Characteristics - Pazopanib. [revised on 2021] [cited 2023 Mar 24]. Available from:
3.Votrient 400 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. 2021 [cited 2023 Mar 24]. Available from
4Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
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