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Home β€Ί Medicine β€Ί Jakavi 5mg Tablet
Substitutes
Jakavi 10mg Tablet
NOVARTIS INDIA LTD
β‚Ή41,025.00
77% costlier

Jakavi 5mg Tablet

Prescription Required
Salt Composition RUXOLITINIB
Marketer NOVARTIS INDIA LTD
Prepaid Only. Non-Returnable.
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This medicine is prepaid
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Introduction to Jakavi 5mg Tablet

Jakavi 5mg Tablet contains ruxolitinib as its active ingredient and belongs to a class of medicines known as kinase inhibitors. It is an advanced anticancer treatment used for myelofibrosis, a rare bone marrow disorder that interferes with normal blood cell formation. It is also indicated for polycythemia vera, a condition in which the body produces an excessive number of red blood cells, particularly in patients who do not respond adequately to hydroxyurea therapy.

In addition, Jakavi 5mg is approved for the treatment of graft-versus-host disease (GVHD) in adults and children aged 12 years and older who have shown an inadequate response to steroid treatment or other systemic therapies.

The dosage of Jakavi 5mg for myelofibrosis is individualized by the physician based on factors such as body weight, blood cell counts, and overall response to treatment. The medication works by inhibiting abnormal signaling pathways responsible for uncontrolled cell growth, thereby helping reduce symptoms like enlarged spleen, fatigue, and disease-related discomfort.

Patients should not take this medicine if they are allergic to ruxolitinib or any of its components. Before starting treatment, inform your doctor if you have a history of tuberculosis, hepatitis B or C, liver disease, kidney disease, or low blood cell counts. Common side effects may include dizziness, headache, swelling, bruising, and decreased platelet levels. Seek medical attention promptly if you experience persistent bleeding, frequent infections, or unusual symptoms.

The price of Jakavi 5mg Tablet in India may vary depending on the pharmacy and location. Patients may choose to buy Jakavi 5mg Tablet online from reliable and verified sources to ensure authenticity. The Novartis Jakavi 5mg price reflects its stringent quality and manufacturing standards. If Jakavi is unavailable, your doctor may recommend an alternative such as Ruxolix; clinical comparisons between Jakavi 5mg and Ruxolix 5mg indicate similar composition and effectiveness.

Eligible patients may also benefit from the Jakavi 5mg Patient Assistance Program, which offers financial support to improve access to treatment. Overall, Jakavi remains a well-established therapy in modern hematology, playing a key role in the management of complex blood and bone marrow disorders.

Uses of Jakavi 5mg Tablet

Jakavi 5mg uses are

Myelofibrosis

Polycythemia vera

Acute-graft-versus-host disease

Chronic-graft-versus-host disease

Therapeutic Effects of Jakavi 5mg Tablet

Jakavi 5mg Tablet (Ruxolitinib) is a targeted anticancer therapy that works by inhibiting specific signaling pathways involved in abnormal cell growth and inflammation. Its main therapeutic effects include: Controls Myelofibrosis Symptoms: Helps reduce symptoms of myelofibrosis such as enlarged spleen, fatigue, night sweats, bone pain, and weight loss, improving overall quality of life. Regulates Blood Cell Production: By inhibiting abnormal JAK signaling, it helps restore better balance in blood cell formation in the bone marrow. Treats Polycythemia Vera: Lowers excessive red blood cell production and reduces the risk of blood clots in patients who are resistant or intolerant to hydroxyurea. Manages Graft-Versus-Host Disease (GVHD): Suppresses overactive immune responses in acute and chronic GVHD, helping control inflammation and tissue damage when other treatments fail. Reduces Disease Progression: Slows disease advancement by blocking pathways that promote uncontrolled cell growth and immune activation. Targeted Action: Acts specifically on disease-causing pathways, offering effective control with less impact on healthy cells compared to conventional chemotherapy. Jakavi 5mg Tablet should be taken under strict medical supervision with regular blood monitoring to ensure safety and optimal therapeutic benefit.

Interaction of Jakavi 5mg Tablet with other drugs

Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional, and supplements and herbal products. Certain medications like fluconazole and other CYP3A4 inhibitors may interact with Jakavi 5mg tablet and reduce its effectiveness by causing undesirable side effects.

More Information about Jakavi 5mg Tablet

Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional, and supplements and herbal products. Certain medications like fluconazole and other CYP3A4 inhibitors may interact with Jakavi 5mg tablet and reduce its effectiveness by causing undesirable side effects.

How to consume Jakavi 5mg Tablet

Your doctor will decide the dose and duration of Jakavi 5mg tablet based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.

Side Effects of Jakavi 5mg Tablet

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Jakavi 5mg side effects are
Common
Low red and white blood cell counts
Low platelet counts
Dizziness, headache
Bruising
Diarrhea
Infections, including viral infections
Swelling in the face and body
Fatigue or tiredness
Serious
Severe infections like hepatitis B
Anemia
Bleeding

Safety Advice for Jakavi 5mg Tablet

Breast Feeding
Unsafe
Breastfeeding is not recommended in patients taking Jakavi 5mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment and for 2 weeks after the last dose.
Alcohol-Consult your doctor
Alcohol
Consult Your Doctor
It is unknown whether consuming alcohol is safe when taking Jakavi 5mg tablet. Inform your physician if you are an alcoholic before starting the treatment.
Liver-unsafe
Liver
Unsafe
Jakavi 5mg tablet should be administered cautiously in patients with liver problems. Dose adjustments are necessary for patients with liver diseases. Inform your physician if you have any liver disorder before the treatment.
Lungs-Consult your doctor
Lungs
Consult Your Doctor
It is unknown whether Jakavi 5mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving-unsafe
Driving
Unsafe
Do not drive or operate heavy machinery if you feel dizzy after taking Jakavi 5mg tablet. Consult your doctor for more advice.
Pregnancy-unsafe
Pregnancy
Unsafe
Do not take Jakavi 5mg tablet if you are pregnant because this may harm the unborn baby. Inform your physician if you are pregnant, suspecting pregnancy, or planning to get pregnant during the treatment.

Word of Advice for Jakavi 5mg Tablet

Stay hydrated and report any unusual symptoms to your doctor immediately.

FAQs about Jakavi 5mg Tablet

Q1. Q1. Can a patient with kidney problems take Jakavi 5mg tablet?

Jakavi 5mg tablet should be cautiously taken if you have any kidney problems. Dose adjustments are necessary for patients with kidney diseases. Inform your doctor if you are on dialysis and have any kidney disorders.

Q2. Q2. I have tuberculosis, and can I take Jakavi 5mg tablet?

Inform your physician if you have active tuberculosis or a past medical history of tuberculosis before starting the treatment with Jakavi 5mg tablet.

Q3. Q3. What foods should I have to avoid while taking Jakavi 5mg tablet?

Grapefruit or grapefruit juice should be avoided while taking Jakavi 5mg tablet. Unless your doctor suggests special diets, you can follow the normal diet.

Q4. Q4. Does Jakavi 5mg tablet weaken the immune system?

The medicine can suppress your immune system and increase your chances of getting infections. Take precautions to prevent illness and injury.

Q5. Q5. What if I overdose or take two doses of Jakavi 5mg tablet?

If you overdosed or took two doses of Jakavi 5mg tablet unknowingly, immediately inform your healthcare professional and seek medical advice.

Fact Box of Jakavi 5mg Tablet

Molecule Name RUXOLITINIB
Marketer NOVARTIS INDIA LTD

References for Jakavi 5mg Tablet

1.Highlights of prescribing information, Ruxolitinib [Revised on 2021 Sep] [cited 2023 Mar 10]. Available from:
2.Jakavi 5mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. www.medicines.org.uk. 2022 [cited 2023 Mar 10]. Available from:
3.Stefanie Ajayi et al; Ruxolitinib; Recent Results in Cancer Research; Published on 2018; Accessed on 13/03/2023;
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