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Home β€Ί Medicine β€Ί Cizumab 300mg Injection
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Cizumab 300mg Injection

Prescription Required
Salt Composition BEVACIZUMAB
Marketer HETERO HEALTHCARE LTD
Prepaid Only. Non-Returnable.
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This medicine is prepaid
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Introduction to Cizumab 300mg Injection

Cizumab 300mg Injection is an anticancer medication containing Bevacizumab as its active ingredient. It works by inhibiting the formation of new blood vessels that supply tumors, thereby slowing or preventing tumor growth. This medicine is used in combination with other chemotherapy agents to treat various cancers, including metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. It is also indicated for the treatment of ovarian, fallopian tube, and primary peritoneal cancers.

Pregnancy, Fertility, and Breastfeeding

Use effective contraception during treatment and for at least six months after the final dose.

This medicine is not recommended for children or adolescents under 18 years of age.

Women planning future pregnancies should discuss fertility preservation options, including ovarian preservation, with their doctor, as this medicine may affect fertility.

Breastfeeding should be avoided, as Bevacizumab may interfere with a child’s growth and development.

Administration and Side Effects

Cizumab 300mg Injection is commonly given in combination with other chemotherapy medicines. Some of the common side effects include constipation, loss of appetite, runny nose, fever, skin reactions, and weight loss.

Warnings and Precautions

Inform your doctor before starting treatment if you have a history of high blood pressure, diabetes, stomach disorders, or heart disease.

This medicine should not be administered within 28 days before or after surgery, as it may increase the risk of poor wound healing and bleeding complications.

Notify your doctor of any dental problems or planned dental surgery before starting treatment.

Report immediately if you experience vision changes, confusion, or neurological symptoms, as these may indicate serious complications

Uses of Cizumab 300mg Injection

Uses of Cizumab 300mg Injection
Cizumab 300mg Injection is indicated to treat the following conditions:

Glioblastoma multiforme (brain cancer)
Persistent, recurrent, or metastatic breast cancer
Metastatic cervical cancer
Advanced kidney cancer
Metastatic colorectal cancer
Advanced non-small-cell lung cancer
Liver Cancer- Hepatocellular carcinoma
Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer

Therapeutic Effects of Cizumab 300mg Injection

Cizumab 300mg Injection is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), which is present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumour. As a result, it slows down the rate of progression of cancer. Lung Cancer: Cizumab 300mg Injection is a monoclonal antibody that has been approved as a first-line treatment for non-small cell lung cancer. For Non-small lung cancer, VEGF and EGFR are the proteins that are involved in promoting tumour growth in lung cancer. Cizumab 300mg Injection binds to these proteins and prevents the spread of lung cancer to other parts. Colorectal Cancer: Cizumab 300mg Injection has been approved initially for treating colorectal cancer as this medicine works by inhibiting the growth of blood vessels within the tumours. Thereby it retards the growth of tumors in colorectal cancer. Also, the latest study has demonstrated that this medication has improved the overall survival rate of patients with advanced colorectal cancer. Breast Cancer: Cizumab 300mg Injection is used in the treatment of metastatic breast cancer along with chemotherapy medications. This medication works against the formation of blood vessels that feed the breast cancer tissue. By producing this action,it makes the breast cancer cells hard to survive and makes them vulnerable to chemotherapy. Brain Cancer: For treating brain cancer, Cizumab 300mg Injection is used along with other chemotherapy medication to prevent the recurrence of brain tumours. It is exhibited as a last resort for brain tumours. Kidney Cancer: Cizumab 300mg Injection is used in combination with interferon-alpha for the treatment of advanced kidney cancer. This medication is effective in metastatic kidney cancer because in this cancer, there is an overexpression of VEGF protein. Ovarian/ fallopian/peritoneal cancer: Cizumab 300mg Injection has been indicted for its use in treating stage iii and iv ovarian cancer, fallopian and peritoneal cancer, along with chemotherapy medications after the initial surgery. This medication can also be used as maintenance therapy or as first-line therapy for patients with platinum-sensitive or resistant chemotherapy patients. Liver Cancer: Cizumab 300mg Injection has been approved for its treatment of advanced liver cancer in combination with immunotherapy. Studies show that this advanced treatment can be used in the frontline for liver cancer as it has exhibited better survival rate in patients compared to the standard therapy.

Interaction of Cizumab 300mg Injection with other drugs

Inform your doctor about any medications you are taking or have taken before the treatment

More Information about Cizumab 300mg Injection

Store Cizumab 300mg Injection at 2˚C to 8˚C. Do not freeze or shake. Protect from light. Keep out of reach of children.

How to consume Cizumab 300mg Injection

Your physician or nurse will administer Cizumab 300mg Injection as an intravenous infusion. The infusion should be given immediately after the dilution.

Side Effects of Cizumab 300mg Injection

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
The side effects of Cizumab 300mg Injection are listed below:
Common:
Headache
Vision changes
Confusion
Severe allergic reactions
High Blood pressure
Delayed wound healing following surgery
Protein in urine
Severe infections
Blood clots in arteries and blood vessels of lungs
Gut perforation
Nosebleeds and bleeding risk
Heart problems with an increase in heart rate
Mouth sores, dryness
Shortness of breath
Rare:
Numbness in hands or feet
Weakness and lack of energy
Diarrhoea, nausea, vomiting, abdominal pain
Constipation
Loss of appetite
Weight loss
Changes in taste and speech
Decrease in counts of white blood cells
Fever
Dry skin
Back pain

Safety Advice for Cizumab 300mg Injection

Breast Feeding
Unsafe
It is recommended to avoid breastfeeding for a minimum of 6 months after your treatment with Cizumab 300mg Injection as this medicine may interfere with the growth of your child.
Alcohol-Consult your doctor
Alcohol
Consult Your Doctor
Consult your doctor to know if it is safe to consume while you are on treatment with Cizumab 300mg Injection, as only limited studies are available.
Liver-Consult your doctor
Liver
Consult Your Doctor
Inform your physician before starting Cizumab 300mg Injection if you have liver disease to avoid any serious side effects.
Lungs-Consult your doctor
Lungs
Consult Your Doctor
Inform your physician before starting Cizumab 300mg Injection if you have lung disease to avoid any serious side effects.
Driving-unsafe
Driving
Unsafe
Avoid driving or using machinery while you are on your treatment with Cizumab 300mg Injection as it is related to causing dizziness or sleepiness.
Pregnancy-Consult your doctor
Pregnancy
Consult Your Doctor
Inform your physician before starting your treatment with Bevacizumab Injection in case if you are pregnant or planning for pregnancy, as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.

Word of Advice for Cizumab 300mg Injection

It is vital to inform your physician before taking Cizumab 300mg Injection if you have the following conditions: Have conditions involving inflammation in the stomach (ulcer, colitis). Experience allergic reactions to Cizumab 300mg Injection or its ingredients. Have recently undergone surgery as it is associated with the risk of bleeding. Have diabetes, hypertension, or heart problems.

FAQs about Cizumab 300mg Injection

Q1. Q1. Is Cizumab 300mg Injection used as a standalone treatment in cancers?

Cizumab 300mg Injection is a recombinant monoclonal antibody that belongs to the immunotherapy class of cancer treatment. It can either be used as monotherapy or in combination with chemotherapy or immunotherapy medications to improve the overall survival rate.

Q2. Q2. Is it safe for women to use Cizumab 300mg Injection?

For women with reproductive potential subjected to Cizumab 300mg Injection, it is advised to discuss with your doctor the effective birth control methods during the treatment. Also to be continued for a minimum of 6 months after the treatment course completion as this medicine may impair fertility.

Q3. Q3. Is it safe to undergo surgery during the treatment with Cizumab 300mg Injection?

Cizumab 300mg Injection is associated with an increased risk of bleeding complications and poor wound healing. Hence, it is suggested to avoid planning for surgery and maintain an interval of 28 days before or after surgery.

Q4. Q4. Do the side effects of Cizumab 300mg Injection last for a chronic period?

All the side effects that are relatively caused by Cizumab 300mg Injection occur until the drug concentration stays in the body. It is found that this medicine will be contained in our body for almost 4 months after the final dose.

Q5. Q5. How is Cizumab 300mg Injection administered?

Cizumab 300mg Injection is given intravenously through infusion, and the amount of drug will be measured based on the patient’s body weight, height and age. The first dose will be administered for 90 minutes, and if well tolerated, the infusion time can be reduced to 30 minutes.

Q6. Q6. Can I take Cizumab 300mg Injection if I am pregnant?

Inform your physician before starting your treatment with Cizumab 300mg Injection in case if you are pregnant or planning for pregnancy, as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.

Fact Box of Cizumab 300mg Injection

Molecule Name BEVACIZUMAB
Marketer HETERO HEALTHCARE LTD

References for Cizumab 300mg Injection

1.Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 21/11/2022],
2.G.G. Dark, A.R. Abdul Razak, Oncology, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 259-282.
3.KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
4.Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
5.Roche Group, U.S FDA, [Revised on Jan 2021][ Accessed on 21/11/2022],
6.Roche Group,Bevacizumab Injection, Indication,[Revised on 2020] [Accessed on 21/11/2022]
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Cizumab 300mg Injection
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12 ML Injection in Vial

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