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Home β€Ί Medicine β€Ί Akynzeo Injection
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Akynzeo Injection

Prescription Required
Salt Composition FOSNETUPITANT,PALONOSETRON
Marketer GLENMARK PHARMACEUTICALS LTD
Prepaid Only. Non-Returnable.
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This medicine is prepaid
only and cannot be
returned once delivered.
12% OFF
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Introduction to Akynzeo Injection

Akynzeo Injection is an anti-emetic medication that contains a fixed-dose combination of two active ingredients: fosnetupitant and palonosetron. Fosnetupitant acts as a neurokinin-1 (NK-1) receptor antagonist, while palonosetron is a 5-HT3 receptor antagonist. Together, they work to prevent chemotherapy-induced nausea and vomiting (CINV).

This medication is prescribed to help cancer patients better tolerate chemotherapy by reducing the frequency and severity of nausea and vomiting. It is also used in the prevention and management of postoperative nausea and vomiting.

Common side effects associated with Akynzeo Injection may include hives, facial swelling, breathing difficulty, and chest pain. Inform your healthcare provider if any of these symptoms persist or become troublesome. Patients with liver disease or renal impairment should notify their physician, as dose adjustments may be required.

There is a potential risk of serotonin syndrome when Akynzeo Injection is used in combination with other serotonergic medicines. Symptoms of serotonin syndrome may include agitation, hallucinations, rapid heart rate, fever, muscle rigidity, impaired coordination, and confusion. Inform your doctor about all medications you are currently taking, especially antidepressants and other serotonergic drugs.

The safety and effectiveness of Akynzeo Injection in pediatric patients have not been established, and it is intended for adult use only. This medication is not recommended during pregnancy, as it may harm the unborn baby. It is also unknown whether Akynzeo passes into breast milk; therefore, breastfeeding women should consult their doctor before using this medicine.

Uses of Akynzeo Injection

Chemotherapy-induced nausea and vomiting.
Postoperative nausea and vomiting.

Therapeutic Effects of Akynzeo Injection

Akynzeo Injection is a fixed-dose combination of two active ingredients, fosnetupitant and palonosetron. Fosnetupitant is a neurokinin-1 (NK-1) receptor antagonist, while palonosetron is a 5-HT3 receptor antagonist. Together, they work by blocking specific receptors in the brain and gut that trigger nausea and vomiting, providing more effective control of these side effects.

Interaction of Akynzeo Injection with other drugs

Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Akynzeo Injection and reduce effectiveness by causing undesirable side effects.

More Information about Akynzeo Injection

Store Akynzeo Injection below (25Β°C). Do not freeze. Keep it out of reach from children and pets.

How to consume Akynzeo Injection

The medicine can be given only as an intravenous injection into a vein by your physician in a hospital setting. Akynzeo Injection is usually administered as a 30-minute infusion before you receive your anti-cancer medicine (chemotherapy) or right before anesthesia for surgery.

Side Effects of Akynzeo Injection

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
Allergic reactions
Hives
Swollen face
Breathing trouble
Chest pain
Common
Headache
Fatigue
Dizziness
Abdominal pain.

Safety Advice for Akynzeo Injection

Breast Feeding
Consult Your Doctor
It is unknown whether Akynzeo Injection passes into breastmilk. Consult your doctor for more advice.
Alcohol-Consult your doctor
Alcohol
Consult Your Doctor
It is unknown whether consuming alcohol interacts with Akynzeo Injection. Please consult your doctor for more advice.
Liver-Consult your doctor
Liver
Consult Your Doctor
It is unknown whether Akynzeo Injection can be used for patients with liver disorders. Inform your physician if you have any liver problems before starting the treatment.
Lungs-Consult your doctor
Lungs
Consult Your Doctor
It is unknown whether Akynzeo Injection can be used for patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Driving-Consult your doctor
Driving
Consult Your Doctor
It is unknown whether Akynzeo Injection alters driving ability. However, if you experience side effects like tiredness or drowsiness, avoid driving and using machines.
Pregnancy-unsafe
Pregnancy
Unsafe
It is unsafe to use Akynzeo Injection in pregnant women because it may cause harm to the baby. Please consult your doctor before taking this medicine.

Word of Advice for Akynzeo Injection

Proper hydration can help reduce the risk of CINV. Drink plenty of fluids, and inform your physician if you have difficulty keeping fluids down. Try to maintain a balanced diet when possible. Eating small, frequent meals and snacks throughout the day can help prevent nausea and vomiting. Stress and anxiety can worsen nausea. Engage in relaxation techniques, such as deep breathing exercises or meditation, to help manage stress. Adequate rest and sleep are also important during the treatment with Akynzeo Injection.

FAQs about Akynzeo Injection

Q1. Q1. What are the possible side effects of Akynzeo Injection?

Akynzeo Injection can cause serious allergic reactions like hives, swollen face, breathing trouble, and chest pain. Some common side effects include headache and constipation.

Q2. Q2. What is the working mechanism of an Akynzeo capsule?

Akynzeo Injection works by blocking the action of a chemical called serotonin, which is involved in causing nausea and vomiting.

Q3. Q3. How effective is Akynzeo Injection in preventing CINV?

Akynzeo Injection is considered effective in preventing chemotherapy-induced nausea and vomiting. It combines two different classes of antiemetic medications (NK-1 receptor antagonist and 5-HT3 receptor antagonist), which can provide more comprehensive control of nausea and vomiting associated with chemotherapy. The effectiveness may vary from person to person, but it is often prescribed to provide significant relief.

Q4. Q4. Who should not take a Akynzeo Injection?

Akynzeo Injection should not be taken by individuals who are allergic to it or its ingredients.

Q5. Q5. What forms does Akynzeo Injection come in?

Akynzeo Injection is available in the form of injection and tablet.

Fact Box of Akynzeo Injection

Molecule Name FOSNETUPITANT,PALONOSETRON
Marketer GLENMARK PHARMACEUTICALS LTD

References for Akynzeo Injection

1.Helsinn Birex Pharmaceuticals, US Food and Drug Administration, [Revised on April 2018] [Accessed on 13th Sept 2023],
2.Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Treatment of bowel motility and water flux disorders, 12th edition, 2011, 1341.
3.KD Tripathi, Essentials of Medical Pharmacology, Antiemetic, prokinetic and digestant drugs, 7th edition, 2013, 669.
In Stock
Akynzeo Injection
β‚Ή4,930.00 MRP β‚Ή5,625.00
Inclusive of all taxes 12% OFF
(You Save β‚Ή695.00)
1 Tab Injection in Vial

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